Enteric nervous system development: migration, differentiation, and disease

JI Lake, RO Heuckeroth - American Journal of Physiology …, 2013 - journals.physiology.org
The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …

The cohesin complex and its roles in chromosome biology

JM Peters, A Tedeschi, J Schmitz - Genes & development, 2008 - genesdev.cshlp.org
Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult

B Zhang, G Arun, YS Mao, Z Lazar, G Hung… - Cell reports, 2012 - cell.com
Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking
protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in …

Cohesin mediates transcriptional insulation by CCCTC-binding factor

KS Wendt, K Yoshida, T Itoh, M Bando, B Koch… - Nature, 2008 - nature.com
Cohesin complexes mediate sister-chromatid cohesion in dividing cells but may also
contribute to gene regulation in postmitotic cells. How cohesin regulates gene expression is …

[HTML][HTML] Cohesins functionally associate with CTCF on mammalian chromosome arms

V Parelho, S Hadjur, M Spivakov, M Leleu, S Sauer… - Cell, 2008 - cell.com
Cohesins mediate sister chromatid cohesion, which is essential for chromosome
segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene …

Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus

S Hadjur, LM Williams, NK Ryan, BS Cobb, T Sexton… - Nature, 2009 - nature.com
Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and
post-replicative DNA repair,. In addition, evidence from model organisms,,, and from human …

A CTCF-independent role for cohesin in tissue-specific transcription

D Schmidt, PC Schwalie, CS Ross-Innes… - Genome …, 2010 - genome.cshlp.org
The cohesin protein complex holds sister chromatids in dividing cells together and is
essential for chromosome segregation. Recently, cohesin has been implicated in mediating …

Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl+/− Mouse, a Model of Cornelia de Lange Syndrome

S Kawauchi, AL Calof, R Santos, ME Lopez-Burks… - PLoS …, 2009 - journals.plos.org
Cornelia de Lange Syndrome (CdLS) is a multi-organ system birth defects disorder linked, in
at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi …

Cornelia de Lange syndrome, cohesin, and beyond

J Liu, ID Krantz - Clinical genetics, 2009 - Wiley Online Library
Cornelia de Lange syndrome (CdLS)(OMIM# 122470,# 300590 and# 610759) is a dominant
genetic disorder with multiple organ system abnormalities which is classically characterized …

Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

J Liu, Z Zhang, M Bando, T Itoh, MA Deardorff… - PLoS …, 2009 - journals.plos.org
Cohesin regulates sister chromatid cohesion during the mitotic cell cycle with Nipped-B-Like
(NIPBL) facilitating its loading and unloading. In addition to this canonical role, cohesin has …