Blood vessels, either in insufficient numbers or in excess, contribute to the pathogenesis of
many diseases. Agents that stimulate angiogenesis can improve blood flow in patients with …

Migration is an essential cellular process that regulates human organ development and
homeostasis as well as disease initiation and progression. In cancer, immune and tumor cell …

INTRODUCTION The collective behavior of cells and insects often relies on self-organizing
processes. By releasing attractant signals, a few individuals can initiate the accumulation …

When cells move using integrin-based focal adhesions, they pull in the direction of motion
with large,∼ 100 Pa, stresses that contract the substrate. Integrin-mediated adhesions …

Tissue wounding induces the rapid recruitment of leukocytes. Wounds and tumours—a type
of 'unhealed wound'—generate hydrogen peroxide (H2O2) through an NADPH oxidase …

Immune cell locomotion is associated with amoeboid migration, a flexible mode of
movement, which depends on rapid cycles of actin polymerization and actomyosin …

Neutrophil recruitment to inflammation sites purportedly depends on sequential waves of
chemoattractants. Current models propose that leukotriene B 4 (LTB 4), a secondary …

Acetaminophen (APAP) is a safe analgesic and antipyretic drug. However, APAP overdose
leads to massive hepatocyte death. Cell death during APAP toxicity occurs by oncotic …

Chemokines orchestrate immune cell trafficking by eliciting either directed or random
migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic …

Dendritic cell (DC) migration in peripheral tissues serves two main functions: antigen
sampling by immature DCs, and chemokine-guided migration towards lymphatic vessels …