Cancer immunotherapy harnesses the ability of the immune system to recognize and
eliminate cancer. The potent ability of dendritic cells (DCs) to initiate and regulate adaptive …

Influenza viruses cause infectious respiratory disease characterized by fever, myalgia, and
congestion, ranging in severity from mild to life-threating. Although enormous efforts have …

Somatic mutations commonly occur in hematopoietic stem cells (HSCs). Some mutant
clones outgrow through clonal hematopoiesis (CH) and produce mutated immune progenies …

Background The conventional type 1 dendritic cell subset (cDC1) is indispensable for tumor
immune responses and the efficacy of immune checkpoint inhibitor (ICI) therapies in animal …

The large family of C-type lectin (CLEC) receptors comprises carbohydrate-binding proteins
that require Ca2+ to bind a ligand. The prototypic receptor is the asialoglycoprotein receptor …

The laboratory mouse is widely considered as a valid and affordable model organism to
study human disease. Attempts to improve the relevance of murine models for the …

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the United
States despite an array of available treatment options. Current standard-of-care …

The efficient activation of professional antigen‐presenting cells—such as dendritic cells
(DC)—in tumors and lymph nodes is critical for the design of next‐generation cancer …

Simple Summary Classic Hodgkin lymphoma (cHL) is one of the most enigmatic study
models of the tumor microenvironment (TME), in which the Hodgkin–Reed Sternberg (HRS) …

Humanized mice are increasingly appreciated as an incredibly powerful platform for
infectious disease research. The often very narrow species tropism of many viral infections …