Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Hydrogen peroxide (H2O2) sensing and signaling involves the reversible oxidation of
particular thiols on particular proteins to modulate protein function in a dynamic manner …

The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the
extracellular space, including hormones and cytokines, as well as cell surface receptors and …

Cellular senescence describes an irreversible growth arrest characterized by distinct
morphology, gene expression pattern, and secretory phenotype. The final or intermediate …

The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

Fungal response to any stress is intricate, specific, and multilayered, though it employs only
a few evolutionarily conserved regulators. This comes with the assumption that one …

Cu/Zn superoxide dismutase (SOD1) is an abundant enzyme that has been best studied as
a regulator of antioxidant defense. Using the yeast Saccharomyces cerevisiae, we report …

Significance: Understanding isoform-and context-specific subcellular Nox reduced
nicotinamide adenine dinucleotide phosphate (NADPH) oxidase compartmentalization …