The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes
sequential behavioral and electrographic changes that can be divided into 3 distinct …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

G-protein coupled receptors (GPCRs) are responsible for a large number of physiological
processes, such as sensory transduction, mediation of hormonal activity, and cell-to-cell …

The general description of kinins refers to these peptides as molecules involved in vascular
tone regulation and inflammation. Nevertheless, in the last years a series of evidences has …

Objective and design: Low level laser therapy (LLLT) has been presented as a novel
therapy to treat inflammation. Herein we studied the effect of LLLT on the COX-2 mRNA …

Injury to peripheral nerves often results in a persistent neuropathic pain condition that is
characterized by spontaneous pain, allodynia, and hyperalgesia. Nerve injury is …

The importance of cholinergic mechanisms for epilepsy was already hinted at by
neurologists at the turn of the nineteenth century (Langley, 1901; Langley and Kato, 1915) …

Introduction: Kinins are main active mediators of the kallikrein–kinin system (KKS) via
bradykinin type 1 inducible (B1R) and type 2 constitutive (B2R) receptors. B2R mediates …