AKAP signaling islands: venues for precision pharmacology
Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …
Molecular mechanisms for cAMP-mediated immunoregulation in T cells–role of anchored protein kinase a signaling units
VL Wehbi, K Taskén - Frontiers in immunology, 2016 - frontiersin.org
The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux
Enzymatic reactions in living cells are highly dynamic but simultaneously tightly regulated.
Enzyme engineers seek to construct multienzyme complexes to prevent intermediate …
Enzyme engineers seek to construct multienzyme complexes to prevent intermediate …
A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis
CS Blaha, G Ramakrishnan, SM Jeon… - Nature …, 2022 - nature.com
Abstract Hexokinase 2 (HK2), which catalyzes the first committed step in glucose
metabolism, is induced in cancer cells. HK2's role in tumorigenesis has been attributed to its …
metabolism, is induced in cancer cells. HK2's role in tumorigenesis has been attributed to its …
Augmentation of CAR T-cell trafficking and antitumor efficacy by blocking protein kinase A localization
K Newick, S O'Brien, J Sun, V Kapoor, S Maceyko… - Cancer immunology …, 2016 - AACR
Antitumor treatments based on the infusion of T cells expressing chimeric antigen receptors
(CAR T cells) are still relatively ineffective for solid tumors, due to the presence of …
(CAR T cells) are still relatively ineffective for solid tumors, due to the presence of …
Phase‐separated multienzyme compartmentalization for terpene biosynthesis in a prokaryote
Liquid–liquid phase separation (LLPS) forms biomolecular condensates or coacervates in
cells. Metabolic enzymes can form phase‐separated subcellular compartments that enrich …
cells. Metabolic enzymes can form phase‐separated subcellular compartments that enrich …
cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes‐associated
protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) …
protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) …
cAMP signaling in subcellular compartments
K Lefkimmiatis, M Zaccolo - Pharmacology & therapeutics, 2014 - Elsevier
In the complex microcosm of a cell, information security and its faithful transmission are
critical for maintaining internal stability. To achieve a coordinated response of all its parts to …
critical for maintaining internal stability. To achieve a coordinated response of all its parts to …
[HTML][HTML] Molecular basis of AKAP specificity for PKA regulatory subunits
Localization of cyclic AMP (cAMP)-dependent protein kinase (PKA) by A kinase-anchoring
proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution …
proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution …
Creating order from chaos: cellular regulation by kinase anchoring
Second messenger responses rely on where and when the enzymes that propagate these
signals become active. Spatial and temporal organization of certain signaling enzymes is …
signals become active. Spatial and temporal organization of certain signaling enzymes is …