[HTML][HTML] Idiosyncratic drug-induced liver injury (IDILI): potential mechanisms and predictive assays
AD Roth, MY Lee - Biomed research international, 2017 - ncbi.nlm.nih.gov
Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute
liver failure (ALF) in the United States. While current drug development processes …
liver failure (ALF) in the United States. While current drug development processes …
[HTML][HTML] African genetic diversity: implications for cytochrome P450-mediated drug metabolism and drug development
I Rajman, L Knapp, T Morgan, C Masimirembwa - EBioMedicine, 2017 - thelancet.com
Genetic diversity is greater in Africa than in other continental populations. Genetic variability
in genes encoding drug metabolizing enzymes may contribute to the high numbers of …
in genes encoding drug metabolizing enzymes may contribute to the high numbers of …
Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine
A Čolić, M Alessandrini, MS Pepper - Drug metabolism reviews, 2015 - Taylor & Francis
The CYP450 and UGT enzymes are involved in phase I and phase II metabolism of the
majority of clinically prescribed drugs, including the non-nucleoside reverse transcriptase …
majority of clinically prescribed drugs, including the non-nucleoside reverse transcriptase …
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana
MJ Maseng, L Tawe, PK Thami, KK Seatla… - Pharmacogenomics …, 2021 - Taylor & Francis
Purpose CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase
inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) …
inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) …
Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean …
D Mhandire, M Lacerda, S Castel… - Omics: a journal of …, 2015 - liebertpub.com
The extremely high prevalence of HIV/AIDS in sub-Saharan Africa and limitations of current
antiretroviral medicines demand new tools to optimize therapy such as pharmacogenomics …
antiretroviral medicines demand new tools to optimize therapy such as pharmacogenomics …
Characterization of CYP2C19 pharmacogenetic variation in African populations and comparison with other global populations
RP Booyse, D Twesigomwe, S Hazelhurst - Pharmacogenomics, 2023 - Future Medicine
Background: CYP2C19 is important in the metabolism of clopidogrel and several
antidepressants. This study aimed to characterize the distribution of CYP2C19 star alleles …
antidepressants. This study aimed to characterize the distribution of CYP2C19 star alleles …
[HTML][HTML] Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes
L Tawe, T Motshoge, P Ramatlho, N Mutukwa… - Scientific reports, 2018 - nature.com
Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6
(CYP2B6) enzyme is important for understanding the differences in clinical responses to …
(CYP2B6) enzyme is important for understanding the differences in clinical responses to …
[HTML][HTML] Pharmacogenomics for infectious diseases in sub-Saharan Africa: successes and opportunities
M Chaudhry, M Alessandrini… - Applied & Translational …, 2016 - ncbi.nlm.nih.gov
The rate of mortality in developing countries due to communicable disease remains
alarmingly high. The leading contributors to disease burden in these regions are the so …
alarmingly high. The leading contributors to disease burden in these regions are the so …
[HTML][HTML] Exporting DNA-striking a balance between preventing exploitation and promoting innovation
MS Pepper - SAMJ: South African Medical Journal, 2017 - scielo.org.za
DNA contains the blueprint of life. Variations in the script determine the great diversity that
characterises our planet. As the analysis of large datasets derived from DNA reveals the …
characterises our planet. As the analysis of large datasets derived from DNA reveals the …
[PDF][PDF] Characterisation of variation in the CYP2C19 gene in African populations
RP Booyse - 2023 - wiredspace.wits.ac.za
Abstract Cytochrome P450 2C19 (CYP2C19) is highly polymorphic, and this accounts in part
for variability in response to clopidogrel and anti-depressants worldwide. However …
for variability in response to clopidogrel and anti-depressants worldwide. However …