Mild hypercortisolism is defined as biochemical evidence of abnormal cortisol secretion
without the classical detectable manifestations of overt Cushing's syndrome and, above all …

Non-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but
regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long …

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …

Benign adrenal tumors cover a spectrum of lesions with distinct morphology and steroid
secretion. Current classification is empirical. Beyond a few driver mutations …

Context Somatic gene mutations have been identified in only about half of cortisol-producing
adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1 …

Simple Summary Using a visual-based clustering method on the TCGA RNA sequencing
data of a large adrenocortical carcinoma (ACC) cohort, we were able to classify these …

The majority of incidentally discovered adrenal tumours are benign adrenocortical
adenomas and the prevalence of adrenocortical adenomas is around 1–7% on cross …

The adrenal cortex produces steroid hormones as adrenocortical hormones in the body,
secreting mineralocorticoids, glucocorticoids, and adrenal androgens, which are all …

The occurrence of different subtypes of endogenous Cushing's syndrome (CS) in single
individuals is extremely rare. We here present the case of a female patient who was …

The intracellular molecular mechanisms underlying the genotype of cortisol-producing
adenoma (CPA) have not been fully determined. We analyzed gene expressions in CPA …