The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

In some mammals, notably humans, recombination occurs almost exclusively where the
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …

To fully exploit the potential of single-cell functional genomics in the study of development
and disease, robust methods are needed to simplify the analysis of data across samples …

Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in
most organisms. DSBs initiate recombination-mediated linking of homologous …

One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …

Sexually reproducing eukaryotes use recombination between homologous chromosomes to
promote chromosome segregation during meiosis. Meiotic recombination is almost …

Double-strand breaks (DSBs) initiate the homologous recombination that is crucial for
meiotic chromosome pairing and segregation. Here, we unveil mouse ANKRD31 as a …

In the current meiotic recombination initiation model, the SPO11 catalytic subunits associate
with MTOPVIB to form a Topoisomerase VI-like complex that generates DNA double strand …

Proper number and placement of meiotic crossovers is vital to chromosome segregation,
with failures in normal crossover distribution often resulting in aneuploidy and infertility …