[HTML][HTML] Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome

A Lonardo, S Ballestri, G Marchesini, P Angulo… - Digestive and Liver …, 2015 - Elsevier
The conventional paradigm of nonalcoholic fatty liver disease representing the “hepatic
manifestation of the metabolic syndrome” is outdated. We identified and summarized …

Serum uric acid levels and risk of metabolic syndrome: a dose-response meta-analysis of prospective studies

H Yuan, C Yu, X Li, L Sun, X Zhu, C Zhao… - The Journal of …, 2015 - academic.oup.com
Context: An excess circulating uric acid level, even within the normal range, is always
comorbid with metabolic syndrome (MS), several of its components, and nonalcoholic fatty …

High uric acid directly inhibits insulin signalling and induces insulin resistance

Y Zhu, Y Hu, T Huang, Y Zhang, Z Li, C Luo… - Biochemical and …, 2014 - Elsevier
Background and aim Accumulating clinical evidence suggests that hyperuricemia is strongly
associated with abnormal glucose metabolism and insulin resistance. However, how high …

[HTML][HTML] Síndrome metabólico: definiciones, epidemiología, etiología, componentes y tratamiento

C Carvajal Carvajal - Medicina Legal de Costa Rica, 2017 - scielo.sa.cr
El síndrome metabólico (SM) es un desorden clínico que se caracteriza por presentar
obesidad abdominal, hipertensión, dislipidemia y resistencia a la insulina. El SM es un …

Dose-response relationship of serum uric acid with metabolic syndrome and non-alcoholic fatty liver disease incidence: a meta-analysis of prospective studies

Z Liu, S Que, L Zhou, S Zheng - Scientific Reports, 2015 - nature.com
Emerging evidence has shown that serum uric acid (SUA) elevation might cause metabolic
derangements, including metabolic syndrome (MetS) and non-alcoholic fatty liver disease …

Effect of uric acid-lowering therapy on blood pressure: systematic review and meta-analysis

L Qu, H Jiang, J Chen - Annals of medicine, 2017 - Taylor & Francis
Background: The purpose of this meta-analysis was to determine if uric acid-lowering
therapy is associated with a decrease in blood pressure (BP) and serum creatinine levels …

Serum uric acid: a strong and independent predictor of metabolic syndrome after adjusting for body composition

TY Yu, JH Jee, JC Bae, SM Jin, JH Baek, MK Lee… - Metabolism, 2016 - Elsevier
Background Some observational studies have suggested that serum uric acid (SUA) levels
are one of the determinants of the metabolic syndrome (MetS). However, previous studies …

Association between hyperuricemia and metabolic syndrome: A cross-sectional study in Tibetan adults on the Tibetan plateau

S Yao, Y Zhou, L Xu, Q Zhang, S Bao… - Frontiers in …, 2022 - frontiersin.org
Purpose This study aimed to assess the relationship of serum uric acid with metabolic
syndrome and its components in Tibetan adults on the Tibetan plateau. Methods A total of …

Hyperuricemia is associated with impaired intestinal permeability in mice

D Xu, Q Lv, X Wang, X Cui, P Zhao… - American Journal …, 2019 - journals.physiology.org
Hyperuricemia is associated with many metabolic diseases. However, the underlying
mechanism remains unknown. The gut microbiota has been demonstrated to play significant …

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase …

Y Zhang, T Yamamoto, I Hisatome, Y Li… - Molecular and cellular …, 2013 - Elsevier
Hyperuricaemia is a disorder of purine metabolism, and is strongly associated with insulin
resistance and abnormal glucose metabolism. As the producer of insulin, pancreatic β cells …