Long-term protective immunity to infectious disease depends on cell-mediated and humoral
immune responses. Induction of a strong humoral response relies on efficient B cell …

Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Objective The ability to regulate B cell development has long been recognized to have
therapeutic potential in a variety of autoimmune diseases. However, despite the presence of …

Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative
syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with FAS …

Autoimmunity is a common phenomenon reported in many globally relevant infections,
including malaria and COVID-19. These and other highly inflammatory diseases have been …

Repetitive or persistent cellular stimulation in vivo has been associated with the
development of a heterogeneous B-cell population that exhibits a distinctive phenotype and …

Abstract Development of B cell memory is a conundrum that scientists are still exploring.
Studies have been conducted in vitro and using advanced animal models to elucidate the …

Introduction B-cells are essential components of the immune system that neutralize
infectious agents through the generation of antigen-specific antibodies and through the …

Background P. vivax malaria is a major global health burden hindering social and economic
development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) …

Background Plasmodium vivax is the dominant Plasmodium spp. causing malaria
throughout tropical and sub-tropical countries. Humoral immunity is induced during P. vivax …