The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is
associated with excessive levels of reactive oxygen species (ROS), which promote a …

Chronic liver disease (CLD) is a growing health concern which accounts for two million
deaths per year. Obesity, alcohol overconsumption, and progressive cholestasis are …

Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen
species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide …

Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which
is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the …

Macrophages play a critical role in the pathogenesis of acetaminophen (APAP)-induced
liver injury (AILI), a major cause of acute liver failure or even death. Sapidolide A (SA) is a …

Chorioamnionitis, commonly referred to as intrauterine infection or inflammation, is
pathologically defined by neutrophil infiltration and inflammation at the maternal-fetal …

Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

Background & Aims Marked enhancement of neutrophil infiltration in the liver is a hallmark of
acute liver failure (ALF), a severe life-threatening disease with varying etiologies. However …

Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced
acute liver injury. Neutrophil elastase is released by neutrophils during inflammation. To …

Acetaminophen (APAP) intoxication is the foremost cause of drug-induced liver failure in
developed countries. The only pharmacologic treatment option, N-acetylcysteine (NAC), is …