The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals,
and materials has grown tremendously over the past ten years. This revolution in chemical …

Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

Biocatalysis has emerged as one of the most promising technologies to enable green
synthesis of important chemicals, due to the ambient conditions generally applied for these …

Biocatalysis has widened its scope and relevance since new molecular tools, including
improved expression systems for proteins, protein and metabolic engineering, and rational …

Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts
in both industry and academia. In the last two decades, the interest in biocatalytic …

This review covers the recent developments (since 2015) of enantioselective
desymmetrization reactions using metal-catalyzed, organocatalyzed and enzymatic …

Highlights•Process intensification through upstream and downstream processing is an
important tool to increase the overall productivity of continuous biocatalysis.•Immobilization …

Continuous‐flow multi‐step synthesis takes the advantages of microchannel flow chemistry
and may transform the conventional multi‐step organic synthesis by using integrated …

Continuous-flow technologies are becoming increasingly relevant in the chemistry field. The
vast arrays of reactor design, in terms of structural geometry, mixing, and residence time, the …