The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

The average lifespan of humans is increasing, and with it the percentage of people entering
the 65 and older age group is growing rapidly and will continue to do so in the next 20 years …

Aging causes a functional decline in tissues throughout the body that may be delayed by
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Background: Skipping breakfast is common among US adults. Limited evidence suggests
that skipping breakfast is associated with atherosclerosis and cardiovascular disease …

Defects in the renal fatty acid oxidation (FAO) pathway have been implicated in the
development of renal fibrosis. Although, compared with young kidneys, aged kidneys show …

Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …

Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and
cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD) …

Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying
mechanisms are poorly understood. Age-related damage to mitochondria may be a critical …

Arterial stiffness is often increased in overweight/obese subjects before the development of
hypertension. It is also one of the earliest indicators of increased cardiovascular disease risk …