Each language has standard books describing that language's grammatical rules. Biologists
have searched for similar, albeit more complex, principles relating enhancer sequence to …

Chordoma is a rare, but often malignant, bone cancer that preferentially affects the axial
skeleton and the skull base. These tumors are both sporadic and hereditary and appear to …

The notochord is a defining feature of all chordates. The transcription factors Zic and ETS
regulate enhancer activity within the notochord. We conduct high-throughput screens of …

The cell type-specific expression of key transcription factors is central to development and
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning …

Background The T-box transcription factor Brachyury (T) is essential for formation of the
posterior mesoderm and the notochord in vertebrate embryos. Work in the frog and the …

It is widely held that the bilaterian tubular gut with mouth and anus evolved from a simple gut
with one major gastric opening. However, there is no consensus on how this happened. Did …

Tissue-specific gene expression is fundamental in development and evolution, and is
mediated by transcription factors and by the cis-regulatory regions (enhancers) that they …

The notochord of the ascidian Ciona consists of only 40 cells, and is a longstanding model
for studying organogenesis in a small, simple embryo. Here, we perform RNAseq on flow …

The notochord is a structure required for support and patterning of all chordate embryos,
from sea squirts to humans. An increasing amount of information on notochord development …

The node and notochord are key tissues required for patterning of the vertebrate body plan.
Understanding the gene regulatory network that drives their formation and function is …