Neuromechanical principles define the properties and problems that shape neural solutions
for movement. Although the theoretical and experimental evidence is debated, we present …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …

In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

As in other neural systems, plasticity is a hallmark of the neural system controlling breathing.
One spinal mechanism of respiratory plasticity is phrenic long‐term facilitation (pLTF) …

Intermittent hypoxia has generally been perceived as a high-risk stimulus, particularly in the
field of sleep medicine, because it is thought to initiate detrimental cardiovascular …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper
and lower motor neuron death. Involvement of respiratory motor neuron pools leads to …

In addition to their well-known roles in the nervous system, there is increasing recognition
that neurotrophins such as brain derived neurotrophic factor (BDNF) as well as their …

While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …