[HTML][HTML] Meiosis: dances between homologs
D Zickler, N Kleckner - Annual Review of Genetics, 2023 - annualreviews.org
The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …
Crossing and zipping: molecular duties of the ZMM proteins in meiosis
A Pyatnitskaya, V Borde, A De Muyt - Chromosoma, 2019 - Springer
Accurate segregation of homologous chromosomes during meiosis depends on the ability of
meiotic cells to promote reciprocal exchanges between parental DNA strands, known as …
meiotic cells to promote reciprocal exchanges between parental DNA strands, known as …
DNA-driven condensation assembles the meiotic DNA break machinery
The accurate segregation of chromosomes during meiosis—which is critical for genome
stability across sexual cycles—relies on homologous recombination initiated by DNA double …
stability across sexual cycles—relies on homologous recombination initiated by DNA double …
[HTML][HTML] Evolution of crossover interference enables stable autopolyploidy by ensuring pairwise partner connections in Arabidopsis arenosa
Polyploidy is a major driver of evolutionary change. Autopolyploids, which arise by within-
species whole-genome duplication, carry multiple nearly identical copies of each …
species whole-genome duplication, carry multiple nearly identical copies of each …
[HTML][HTML] Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes
I Dereli, V Telychko, F Papanikos… - Nature …, 2024 - nature.com
Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in
most organisms. DSBs initiate recombination-mediated linking of homologous …
most organisms. DSBs initiate recombination-mediated linking of homologous …
[HTML][HTML] PRDM9, a driver of the genetic map
C Grey, F Baudat, B de Massy - PLoS genetics, 2018 - journals.plos.org
During meiosis, maternal and paternal chromosomes undergo exchanges by homologous
recombination. This is essential for fertility and contributes to genome evolution. In many …
recombination. This is essential for fertility and contributes to genome evolution. In many …
[HTML][HTML] PRDM9 methyltransferase activity is essential for meiotic DNA double-strand break formation at its binding sites
The programmed formation of hundreds of DNA double-strand breaks (DSBs) is essential for
proper meiosis and fertility. In mice and humans, the location of these breaks is determined …
proper meiosis and fertility. In mice and humans, the location of these breaks is determined …
Crossover interference: shedding light on the evolution of recombination
SP Otto, BA Payseur - Annual review of genetics, 2019 - annualreviews.org
Through recombination, genes are freed to evolve more independently of one another,
unleashing genetic variance hidden in the linkage disequilibrium that accumulates through …
unleashing genetic variance hidden in the linkage disequilibrium that accumulates through …
[HTML][HTML] REC114 partner ANKRD31 controls number, timing, and location of meiotic DNA breaks
Double-strand breaks (DSBs) initiate the homologous recombination that is crucial for
meiotic chromosome pairing and segregation. Here, we unveil mouse ANKRD31 as a …
meiotic chromosome pairing and segregation. Here, we unveil mouse ANKRD31 as a …
Conservation and divergence of meiotic DNA double strand break forming mechanisms in Arabidopsis thaliana
N Vrielynck, K Schneider, M Rodriguez… - Nucleic acids …, 2021 - academic.oup.com
In the current meiotic recombination initiation model, the SPO11 catalytic subunits associate
with MTOPVIB to form a Topoisomerase VI-like complex that generates DNA double strand …
with MTOPVIB to form a Topoisomerase VI-like complex that generates DNA double strand …