Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

Carriers are equally important as drugs. They can substantially improve bioavailability of
cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently …

Abstract Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's
disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that …

The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Nanotechnology refers to the control, manipulation, study and manufacture of structures and
devices at the nanometer size range. The small size, customized surface, improved solubility …

For decades infections have been treated easily with drugs. However, in the 21st century,
they may become lethal again owing to the development of antimicrobial resistance …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Nanoscience has matured significantly during the last decade as it has transitioned from
bench top science to applied technology. Presently, nanomaterials are used in a wide …

Polymeric biomaterials have found widespread applications in nanomedicine, and poly
(lactide-co-glycolide),(PLGA) in particular has been successfully implemented in numerous …