Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Collective cell migration underlies morphogenesis, wound healing and cancer invasion,.
Most directed migration in vivo has been attributed to chemotaxis, whereby cells follow a …

Mechanical force controls fundamental cellular processes in health and disease, and
increasing evidence shows that the nucleus both experiences and senses applied forces …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

Cell function depends on tissue rigidity, which cells probe by applying and transmitting
forces to their extracellular matrix, and then transducing them into biochemical signals. Here …