The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Exosomes in cancer development, metastasis, and immunity

L Zhang, D Yu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
Exosomes play essential roles in intercellular communications. The exosome was
discovered in 1983, when it was found that reticulocytes release 50-nm small vesicles …

The Yin and Yang of exosome isolation methods: conventional practice, microfluidics, and commercial kits

SZ Shirejini, F Inci - Biotechnology Advances, 2022 - Elsevier
Exosomes are a subset of extracellular vesicles released from various cells, and they can be
found in different bodily fluids. Exosomes have been utilized as biomarkers to diagnose …

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

S Tan, Y Yang, W Yang, Y Han, L Huang… - Journal of Experimental …, 2023 - Springer
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications

Q Yang, J Xu, J Gu, H Shi, J Zhang, J Zhang… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

Isobaric labeling-based relative quantification in shotgun proteomics

N Rauniyar, JR Yates III - Journal of proteome research, 2014 - ACS Publications
Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Exosomes as smart drug delivery vehicles for cancer immunotherapy

H Zhang, S Wang, M Sun, Y Cui, J Xing… - Frontiers in …, 2023 - frontiersin.org
Exosomes (Exos) as drug delivery vehicles have been widely used for cancer
immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity …

A comparison of traditional and novel methods for the separation of exosomes from human samples

LL Yu, J Zhu, JX Liu, F Jiang, WK Ni… - BioMed research …, 2018 - Wiley Online Library
Exosomes are discrete populations of small (40‐200 nm in diameter) membranous vesicles
that are released into the extracellular space by most cell types, eventually accumulating in …

[HTML][HTML] Small extracellular vesicles in cancer

K Abhange, A Makler, Y Wen, N Ramnauth, W Mao… - Bioactive Materials, 2021 - Elsevier
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art

SM Mousavi, SMA Mahdian, MS Ebrahimi… - … Therapy-Nucleic Acids, 2022 - cell.com
Exosomes are small extracellular vesicles with sizes ranging from 30–150 nanometers that
contain proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived from the …