Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia
E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …
preterm infants. A key histopathological feature of BPD is stunted late lung development …
Antenatal corticosteroids: a reappraisal of the drug formulation and dose
We review the history of antenatal corticosteroid therapy (ACS) and present recent
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …
Pharmacokinetics and pharmacodynamics of intramuscular and oral betamethasone and dexamethasone in reproductive age women in India
AH Jobe, MA Milad, T Peppard… - Clinical and translational …, 2020 - Wiley Online Library
High‐dose betamethasone and dexamethasone are standard of care treatments for women
at risk of preterm delivery to improve neonatal respiratory and mortality outcomes. The dose …
at risk of preterm delivery to improve neonatal respiratory and mortality outcomes. The dose …
Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation
Background Antenatal steroid therapy for fetal lung maturation is routinely administered to
women at risk of preterm delivery. There is strong evidence to demonstrate benefit from …
women at risk of preterm delivery. There is strong evidence to demonstrate benefit from …
[HTML][HTML] Prenatal inflammation enhances antenatal corticosteroid–induced fetal lung maturation
Respiratory complications are the major cause of morbidity and mortality among preterm
infants, which is partially prevented by the administration of antenatal corticosteroids (ACS) …
infants, which is partially prevented by the administration of antenatal corticosteroids (ACS) …
A comparison of 2 doses of antenatal dexamethasone for the prevention of respiratory distress syndrome: an open-label, noninferiority, pragmatic randomized trial
S Chawanpaiboon, R Chukaew, J Pooliam - American Journal of …, 2024 - Elsevier
Background Antenatal corticosteroids have been used for the prevention of respiratory
complications, intraventricular hemorrhage, necrotizing enterocolitis, and other adverse …
complications, intraventricular hemorrhage, necrotizing enterocolitis, and other adverse …
[HTML][HTML] Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the World Health Organization dexamethasone regimen …
Background The intramuscular administration of antenatal steroids to women at risk of
preterm delivery achieves high maternal and fetal plasma steroid concentrations, which are …
preterm delivery achieves high maternal and fetal plasma steroid concentrations, which are …
Extremely preterm children exhibit altered cortical thickness in language areas
ME Barnes-Davis, BJ Williamson, SL Merhar… - Scientific reports, 2020 - nature.com
Children born extremely preterm (< 28 weeks gestation, EPT) are at increased risk for
language and other neurocognitive deficits compared to term controls (TC). Prior studies …
language and other neurocognitive deficits compared to term controls (TC). Prior studies …
The rhesus macaque serves as a model for human lateral branch nephrogenesis
MP Schuh, L Alkhudairy, A Potter… - Journal of the …, 2021 - journals.lww.com
Background Most nephrons are added in late gestation. Truncated extrauterine
nephrogenesis in premature infants results in fewer nephrons and significantly increased …
nephrogenesis in premature infants results in fewer nephrons and significantly increased …
The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation
Background Antenatal corticosteroids (ACS) are the standard of care for maturing the fetal
lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains …
lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains …