Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

Antenatal corticosteroids: a reappraisal of the drug formulation and dose

AH Jobe, M Kemp, A Schmidt, T Takahashi… - Pediatric …, 2021 - nature.com
We review the history of antenatal corticosteroid therapy (ACS) and present recent
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …

Pharmacokinetics and pharmacodynamics of intramuscular and oral betamethasone and dexamethasone in reproductive age women in India

AH Jobe, MA Milad, T Peppard… - Clinical and translational …, 2020 - Wiley Online Library
High‐dose betamethasone and dexamethasone are standard of care treatments for women
at risk of preterm delivery to improve neonatal respiratory and mortality outcomes. The dose …

Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation

SWD Carter, EL Fee, H Usuda, G Oguz, A Ramasamy… - BMC medicine, 2024 - Springer
Background Antenatal steroid therapy for fetal lung maturation is routinely administered to
women at risk of preterm delivery. There is strong evidence to demonstrate benefit from …

[HTML][HTML] Prenatal inflammation enhances antenatal corticosteroid–induced fetal lung maturation

AF Schmidt, PS Kannan, J Bridges, P Presicce… - JCI insight, 2020 - ncbi.nlm.nih.gov
Respiratory complications are the major cause of morbidity and mortality among preterm
infants, which is partially prevented by the administration of antenatal corticosteroids (ACS) …

A comparison of 2 doses of antenatal dexamethasone for the prevention of respiratory distress syndrome: an open-label, noninferiority, pragmatic randomized trial

S Chawanpaiboon, R Chukaew, J Pooliam - American Journal of …, 2024 - Elsevier
Background Antenatal corticosteroids have been used for the prevention of respiratory
complications, intraventricular hemorrhage, necrotizing enterocolitis, and other adverse …

[HTML][HTML] Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the World Health Organization dexamethasone regimen …

H Usuda, EL Fee, S Carter, L Furfaro… - American Journal of …, 2022 - Elsevier
Background The intramuscular administration of antenatal steroids to women at risk of
preterm delivery achieves high maternal and fetal plasma steroid concentrations, which are …

Extremely preterm children exhibit altered cortical thickness in language areas

ME Barnes-Davis, BJ Williamson, SL Merhar… - Scientific reports, 2020 - nature.com
Children born extremely preterm (< 28 weeks gestation, EPT) are at increased risk for
language and other neurocognitive deficits compared to term controls (TC). Prior studies …

The rhesus macaque serves as a model for human lateral branch nephrogenesis

MP Schuh, L Alkhudairy, A Potter… - Journal of the …, 2021 - journals.lww.com
Background Most nephrons are added in late gestation. Truncated extrauterine
nephrogenesis in premature infants results in fewer nephrons and significantly increased …

The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation

MW Kemp, M Saito, AF Schmidt, H Usuda… - American journal of …, 2020 - Elsevier
Background Antenatal corticosteroids (ACS) are the standard of care for maturing the fetal
lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains …