SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines

S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development

S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …

COVID-19 vaccines: current and future perspectives

L Soraci, F Lattanzio, G Soraci, ME Gambuzza… - Vaccines, 2022 - mdpi.com
Currently available vaccines against severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) are highly effective but not able to keep the coronavirus disease 2019 …

[HTML][HTML] Therapeutic dilemmas in addressing SARS-CoV-2 infection: Favipiravir versus Remdesivir

PA Negru, AF Radu, CM Vesa, T Behl… - Biomedicine & …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) represents an unmet clinical need, due to a
high mortality rate, rapid mutation rate in the virus, increased chances of reinfection, lack of …

SARS-CoV-2 and emerging variants: unmasking structure, function, infection, and immune escape mechanisms

J Li, H Jia, M Tian, N Wu, X Yang, J Qi… - Frontiers in Cellular …, 2022 - frontiersin.org
As of April 1, 2022, over 468 million COVID-19 cases and over 6 million deaths have been
confirmed globally. Unlike the common coronavirus, SARS-CoV-2 has highly contagious …

Molecular evolution of SARS-CoV-2 during the COVID-19 pandemic

LD González-Vázquez, M Arenas - Genes, 2023 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced diverse
molecular variants during its recent expansion in humans that caused different …

SARS-CoV-2 nucleocapsid protein targets a conserved surface groove of the NTF2-like domain of G3BP1

M Biswal, J Lu, J Song - Journal of Molecular Biology, 2022 - Elsevier
Stress granule (SG) formation mediated by Ras GTPase-activating protein-binding protein 1
(G3BP1) constitutes a key obstacle for viral replication, which makes G3BP1 a frequent …

SARS‐CoV‐2 nucleocapsid: Biological functions and implication for disease diagnosis and vaccine design

F Maghsood, A Ghorbani, H Yadegari… - Reviews in Medical …, 2023 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is transmitted by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has affected millions of …

Identification of intrinsically disorder regions in non-structural proteins of SARS-CoV-2: New insights into drug and vaccine resistance

F Anjum, T Mohammad, P Asrani, A Shafie… - Molecular and Cellular …, 2022 - Springer
The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged
in December 2019 and caused coronavirus disease 2019 (COVID-19), which causes …

COVID-19 diagnosis and SARS-CoV-2 strain identification by a rapid, multiplexed, point-of-care antibody microarray

JT Heggestad, RJ Britton, DS Kinnamon, J Liu… - Analytical …, 2023 - ACS Publications
Antigen tests to detect SARS-CoV-2 have emerged as a promising rapid diagnostic method
for COVID-19, but they are unable to differentiate between variants of concern (VOCs). Here …