During angiogenesis, new vessels emerge from existing endothelial lined vessels to
promote the degradation of the vascular basement membrane and remodel the extracellular …

Background The aim of this systematic review (SR) was to summarize and critically appraise
available evidence on the association of the immunohistochemical expression of matrix …

Oral squamous cell carcinoma (OSCC) is the fifth common cause of cancer mortality in
Taiwan with high incidence and recurrence and needs new therapeutic strategies. In this …

Background/Aims: Periapical periodontitis is caused by bacterial infection and results in both
one destruction and tooth loss. Osteopontin (OPN) is a secreted phosphorylated …

Simple Summary Cancer-associated fibroblasts (CAFs) are the major cellular component of
the tumor microenvironment and have been shown to stimulate tumor growth, epithelial-to …

Simple Summary The crucial role of tumor-associated macrophages (TAMs) in the disease
progression of various types of tumors, including esophageal squamous cell carcinoma …

The clinical management of oral cancer is often frequented with challenges that arise from
relapse, recurrence, invasion and resistance towards the cornerstone chemo and radiation …

Abstract Matrix metalloproteinase-9 (MMP-9) is a gelatinase, which is a member of the
MMPs family. We know that MMP-9 is not only an important gelatinase to regulate the …

Tumor-associated neutrophils (TANs) promote metastasis of multiple cancers, including oral
squamous cell carcinoma (OSCC). Melatonin (Mel) reportedly exerts anti-metastatic effects …

Papillary thyroid carcinoma (PTC), a common form of thyroid malignancy, displays
significant variations in clinical features and outcome. The malignant transformation of the …