Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …

Abstract Polo-like kinase 1 (PLK1) plays an important role in the initiation, maintenance, and
completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

Abstract Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors,
being frequently considered as an oncogene and an attractive cancer target. However, its …

Breast cancers are composed of molecularly distinct subtypes with different clinical
outcomes and responses to therapy. To discover potential therapeutic targets for the poor …

Despite dramatic advances in cancer research and therapy, breast cancer remains a tricky
health problem and represents a top biomedical research priority. Nowadays, breast cancer …

Despite controversy on the correlation between p53 accumulation and TP53 mutational
status, ihas long been used as a surrogate method for mutation analysis. The aim of our …

Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics,
mainly microtubule-targeting agents (MTAs), such as taxanes and vinca alkaloids, are …

Polo-like kinase 1 (Plk1) plays key roles in regulating mitotic processes that are crucial for
cellular proliferation. Overexpression of Plk1 is tightly associated with the development of …

Abstract The Nek2 and Plk4 kinases serve as crucial regulators of mitotic processes such as
the centrosome duplication cycle and spindle assembly. Deregulation of these processes …