Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

SB Chidambaram, MM Essa, AG Rathipriya… - Pharmacology & …, 2022 - Elsevier
The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine

MS Lener, MJ Niciu, ED Ballard, M Park, LT Park… - Biological …, 2017 - Elsevier
In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …

[HTML][HTML] The neuro-endocrinological role of microbial glutamate and GABA signaling

R Mazzoli, E Pessione - Frontiers in microbiology, 2016 - frontiersin.org
Gut microbiota provides the host with multiple functions (eg, by contributing to food
digestion, vitamin supplementation, and defense against pathogenic strains) and interacts …

Interrogation of the mammalian gut–brain axis using LC–MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic …

TD Horvath, SJ Haidacher, MA Engevik, B Luck… - Nature …, 2023 - nature.com
Interest in the communication between the gastrointestinal tract and central nervous system,
known as the gut–brain axis, has prompted the development of quantitative analytical …

Increasing Nrf2 activity as a treatment approach in neuropsychiatry

G Morris, AJ Walker, K Walder, M Berk, W Marx… - Molecular …, 2021 - Springer
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of 1H-MRS studies

E Scotti-Muzzi, K Umla-Runge… - European …, 2021 - Elsevier
The anterior cingulate cortex (ACC), a brain region that mediates affect and cognition by
connecting the frontal cortex to limbic structures, has been consistently implicated in the …

[HTML][HTML] GABA system in schizophrenia and mood disorders: a mini review on third-generation imaging studies

C Chiapponi, F Piras, F Piras, C Caltagirone… - Frontiers in …, 2016 - frontiersin.org
Third-generation neuroimaging research has been enriched by advances in magnetic
resonance spectroscopy (MRS) measuring the concentration of important neurotrasmitters …

[HTML][HTML] Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study

B Isler, N Von Burg, T Kleinjung, M Meyer, P Stämpfli… - Scientific Reports, 2022 - nature.com
We performed magnetic resonance spectroscopy (MRS) on healthy individuals with tinnitus
and no hearing loss (n= 16) vs. a matched control group (n= 17) to further elucidate the role …

[HTML][HTML] Glutamatergic and N-acetylaspartate metabolites in bipolar disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy …

J Chabert, E Allauze, B Pereira, C Chassain… - International Journal of …, 2022 - mdpi.com
The exact neurobiological mechanisms of bipolar disorder (BD) remain unknown. However,
some neurometabolites could be implicated, including Glutamate (Glu), Glutamine (Gln) …