The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …

The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the
onset and progression of Alzheimer's disease. Although this observation has prompted an …

The amyloid-β hypothesis of Alzheimer's Disease (AD) focuses on accumulation of amyloid-
β peptide (Aβ) as the main culprit for the myriad physiological changes seen during …

The cellular polyamines spermine, spermidine, and their metabolic precursor putrescine,
have long been associated with cell-growth, tumor-related gene regulations, and …

IDPs (intrinsically disordered proteins) play crucial roles in many important cellular
processes such as signalling or transcription and are attractive therapeutic targets for …

In this work we present and compare the results of extensive molecular dynamics
simulations of model systems comprising an Aβ 1–40 peptide in water in interaction with …

Aggregation of β‐amyloid (Aβ) into oligomers and further into fibrils is hypothesized to be a
key factor in pathology of Alzheimer's disease (AD). In this study, mapping and docking were …

Using all-atom explicit water model and replica exchange molecular dynamics, we study the
interactions between Aβ monomer and nonsteroidal anti-inflammatory drug ibuprofen, which …

We recently reported that a glycopeptidomimetic molecule significantly delays the
fibrillization process of Aβ42 peptide involved in Alzheimer's disease. However, the binding …

Amyloid-β peptides and their metal-associated aggregated states have been implicated in
the pathogenesis of Alzheimer's disease. The present paper epitomises the design and …