Metagenomic sequencing data provide a rich resource from which to expand our
understanding of differential protein functions involved in human health. Here, we outline a …

Host‐associated and environmental microbiomes play central roles in human health,
biogeochemical cycling, response to ecosystem change, and agriculture. Scientific …

Bile acids (BAs) are a class of endogenous metabolites with important functions. As
amphipathic molecules, BAs have strong antibacterial effects, preventing overgrowth of the …

Three Gram-stain-negative, facultatively anaerobic, rod-shaped, catalase-positive, oxidase-
negative bacterial strains were designated as hw1T, hw8T and hw3T. Strains hw1T, hw8T …

Bile acids are important gut microbiota metabolites that regulate both host and microbial
functions. To identify the direct protein targets of bile acids in Enterococcus, we synthesized …

Drugs intended to target mammalian cells can have broad off‐target effects on the human
gut microbiota with potential downstream consequences for drug efficacy and side effect …

Activity-based protein profiling (ABPP) is a powerful chemical approach for probing protein
function and enzymatic activity in complex biological systems. This strategy typically utilizes …

The gut microbiota offers an extensive resource of enzymes, but many remain
uncharacterized. To distinguish the activities of similar annotated proteins and mine the …

Multi-omic analyses can provide information on the potential for activity within a microbial
community but often lack specificity to link functions to cell, primarily offer potential for …

Bacteria are ubiquitous lifeforms with important roles in the environment, biotechnology, and
human health. Many of the functions that bacteria perform are mediated by proteins and …