The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated …

Extracellular vesicles (EVs) contain a plethora of biomolecules, including nucleic acids, with
diverse diagnostic and therapeutic application potential. Although reverse transcription …

The aggregation of amyloidogenic proteins is a pathological hallmark of various
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and …

Guanine-rich DNA sequences are known to fold into secondary structures called G-
quadruplexes (G4s), which can form from either individual DNA strands (intra-molecular) or …

Stress granules (SGs) are non-membranous organelles facilitating stress responses and
linking the pathology of age-related diseases. In a genome-wide imaging-based phenomic …

Given the emergence of the severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐
2), which particularly threatens older people with comorbidities such as diabetes mellitus …

Prions are self‐perpetuating proteins able to switch between a soluble state and an
aggregated‐and‐transmissible conformation. These proteinaceous entities have been …

The prion protein is a multifunctional protein that exists in at least two different folding states.
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …