Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

Liver fibrosis is the common pathological basis of all chronic liver diseases, and is the
necessary stage for the progression of chronic liver disease to cirrhosis. As one of …

The extracellular matrix of cirrhotic liver tissue is highly crosslinked. Here we show that
advanced glycation end-products (AGEs) mediate crosslinking in liver extracellular matrix …

Members of the MMP family function in various processes of innate immunity, particularly in
controlling important steps in leukocyte trafficking and activation. MMP28 (epilysin) is a …

Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute
lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV …

Background: Hepatic stellate cells (HSCs) are the primary collagen-secreting cells in the
liver. While HSCs are the major cell type involved in the pathogenesis of liver fibrosis …

Macrophages have been found to both promote liver fibrosis and contribute to its resolution
by acquiring different phenotypes based on signals from the micro-environment. The best …

Following inhalation into the lungs, silica particles are engulfed by alveolar macrophages,
which triggers endogenous or exogenous apoptosis signaling pathways. As an inducer of …

Liver diseases have been a common challenge for people all over the world, which
threatens the quality of life and safety of hundreds of millions of patients. China is a major …

Background Silicosis is characterized by accumulation of fibroblasts and excessive
deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 …