Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
[HTML][HTML] Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update
FM Cordero, D Giomi, F Machetti - Reactions, 2024 - mdpi.com
The present review is a comprehensive update of the synthesis of monocyclic β-lactams via
cycloaddition reactions. According to the IUPAC definition of cycloaddition, both elementary …
cycloaddition reactions. According to the IUPAC definition of cycloaddition, both elementary …
Potent antiproliferative active agents: novel bis Schiff bases and bis spiro β-lactams bearing isatin tethered with butylene and phenylene as spacer and DNA/BSA …
Abstract A [2+ 2]-cycloaddition of bis-isatin Schiff bases 5a–b and 7 with activated
aryloxyacetic acid derivatives 8a–d afforded bis-spiroisatino β-lactams with aliphatic and …
aryloxyacetic acid derivatives 8a–d afforded bis-spiroisatino β-lactams with aliphatic and …
Molecular docking, synthesis and evaluation of the antimicrobial, antiproliferative, and antioxidant properties of β-lactam bisindoles
S Ranjbari, A Jarrahpour, S Kianpour, S Sepehri… - Journal of Molecular …, 2023 - Elsevier
A series of novel bis (indolyl) methane-β-lactam hybrids has been efficiently synthesized by
a [2+ 2]-cycloaddition reaction of imines 5a-c with ketenes derived from substituted acetic …
a [2+ 2]-cycloaddition reaction of imines 5a-c with ketenes derived from substituted acetic …
Synthesis, in vitro Antimicrobial assay and Molecular Docking Studies of some new Symmetrical Bis-Schiff Bases and their 2-Azetidinones.
SA Hassan, DM Aziz - Zanco Journal of Pure and …, 2021 - zancojournal.su.edu.krd
Four membered cyclic amides that are a broadly utilized class of antimicrobial agents up to
now. Moreover, Symmetrical Bis-Schiff bases constitute an extraordinary class of strained …
now. Moreover, Symmetrical Bis-Schiff bases constitute an extraordinary class of strained …
Sulfonamide‐β‐lactam Hybrids Incorporating the Piperazine Moiety as Potential Antiinflammatory Agent with Promising Antibacterial Activity
Several monocyclic β‐lactams have been synthesized via a [2+ 2] ketene–imine
cycloaddition reaction (Staudinger reaction) and evaluated for their biological activities. The …
cycloaddition reaction (Staudinger reaction) and evaluated for their biological activities. The …
Novel N-α-amino acid spacer-conjugated phthalimide–triazine derivatives: synthesis, antimicrobial and molecular docking studies
P Asadi, E Khodamoradi, G Khodarahmi… - Amino Acids, 2023 - Springer
To design and develop novel antimicrobial agents, a series of phthalimide–triazine-based
derivatives (6a–6e) were synthesized, characterized and evaluated for their potential …
derivatives (6a–6e) were synthesized, characterized and evaluated for their potential …
Molecular Docking and Antibacterial Assessment of Monocyclic β‐Lactams against Broad‐Spectrum and Nosocomial Multidrug‐Resistant Pathogens
Abstract β‐Lactam antibiotics are critical antibacterial agents and have rapidly become
active ingredients in modern medicine. On the other hand, in the face of increasing rate of …
active ingredients in modern medicine. On the other hand, in the face of increasing rate of …
Synthesis of α‐Heterocycle Anchored Spirocyclic Azetidin‐2‐ones in a Minute by p‐TSA Catalyzed Cyclocondensation of Azetidin‐2,3‐diones with Difunctionalized …
Abstract Monocyclic azetidin‐2, 3‐diones provide easy extensions to spiro‐fused azetidin‐2‐
ones upon p‐toluenesulfonic acid (p‐TSA) catalyzed cyclocondensation reaction with …
ones upon p‐toluenesulfonic acid (p‐TSA) catalyzed cyclocondensation reaction with …
Insights into the anticancer activity of chiral alkylidene-β-lactams and alkylidene-γ-lactams: Synthesis and biological investigation
Chiral alkylidene-β-lactams and alkylidene-γ-lactams were synthesized and screened for
their in vitro activity against four human cancer cell lines (melanoma, esophageal, lung and …
their in vitro activity against four human cancer cell lines (melanoma, esophageal, lung and …