The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs

TC Johnstone, K Suntharalingam, SJ Lippard - Chemical reviews, 2016 - ACS Publications
The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Application of light scattering techniques to nanoparticle characterization and development

PM Carvalho, MR Felício, NC Santos… - Frontiers in …, 2018 - frontiersin.org
Over the years, the scientific importance of nanoparticles for biomedical applications has
increased. The high stability and biocompatibility, together with the low toxicity of the …

Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology

N Bertrand, J Wu, X Xu, N Kamaly… - Advanced drug delivery …, 2014 - Elsevier
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …

Late‐stage peptide diversification by position‐selective C− H activation

W Wang, MM Lorion, J Shah, AR Kapdi… - Angewandte Chemie …, 2018 - Wiley Online Library
The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Peptide-based cancer therapy: opportunity and challenge

D Wu, Y Gao, Y Qi, L Chen, Y Ma, Y Li - Cancer letters, 2014 - Elsevier
Cancer is one of the leading causes of death worldwide. Conventional cancer therapies
mainly focus on mass cell killing without high specificity and often cause severe side effects …

New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

L Mendive-Tapia, S Preciado, J García… - Nature …, 2015 - nature.com
Natural peptides show high degrees of specificity in their biological action. However, their
therapeutical profile is severely limited by their conformational freedom and metabolic …

Biomolecules-derived biomaterials

LP Datta, S Manchineella, T Govindaraju - Biomaterials, 2020 - Elsevier
Human civilization has witnessed the use of materials-derived from biomolecules of plants
and animal origin for biomedical applications since ancient era. In recent years, precision …

Platinum coordination compounds with potent anticancer activity

KM Deo, DL Ang, B McGhie, A Rajamanickam… - Coordination Chemistry …, 2018 - Elsevier
Many international researchers have strived to understand the mechanism of action or
improve the efficacy of inorganic coordination compounds that have been identified to …

Anticancer peptides mechanisms, simple and complex

P Norouzi, M Mirmohammadi, MHH Tehrani - Chemico-Biological …, 2022 - Elsevier
Peptide therapy has started since 1920s with the advent of insulin application, and now it
has emerged as a new approach in treatment of diseases including cancer. Using anti …