The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs
TC Johnstone, K Suntharalingam, SJ Lippard - Chemical reviews, 2016 - ACS Publications
The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …
but new platinum agents have been very slow to enter the clinic. Recently, however, there …
Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …
Application of light scattering techniques to nanoparticle characterization and development
Over the years, the scientific importance of nanoparticles for biomedical applications has
increased. The high stability and biocompatibility, together with the low toxicity of the …
increased. The high stability and biocompatibility, together with the low toxicity of the …
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …
field has experienced an exponential growth since early 2000's. The path to the …
Late‐stage peptide diversification by position‐selective C− H activation
The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …
Peptide-based cancer therapy: opportunity and challenge
D Wu, Y Gao, Y Qi, L Chen, Y Ma, Y Li - Cancer letters, 2014 - Elsevier
Cancer is one of the leading causes of death worldwide. Conventional cancer therapies
mainly focus on mass cell killing without high specificity and often cause severe side effects …
mainly focus on mass cell killing without high specificity and often cause severe side effects …
New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues
L Mendive-Tapia, S Preciado, J García… - Nature …, 2015 - nature.com
Natural peptides show high degrees of specificity in their biological action. However, their
therapeutical profile is severely limited by their conformational freedom and metabolic …
therapeutical profile is severely limited by their conformational freedom and metabolic …
Biomolecules-derived biomaterials
Human civilization has witnessed the use of materials-derived from biomolecules of plants
and animal origin for biomedical applications since ancient era. In recent years, precision …
and animal origin for biomedical applications since ancient era. In recent years, precision …
Platinum coordination compounds with potent anticancer activity
Many international researchers have strived to understand the mechanism of action or
improve the efficacy of inorganic coordination compounds that have been identified to …
improve the efficacy of inorganic coordination compounds that have been identified to …
Anticancer peptides mechanisms, simple and complex
P Norouzi, M Mirmohammadi, MHH Tehrani - Chemico-Biological …, 2022 - Elsevier
Peptide therapy has started since 1920s with the advent of insulin application, and now it
has emerged as a new approach in treatment of diseases including cancer. Using anti …
has emerged as a new approach in treatment of diseases including cancer. Using anti …