Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Cancer led to the deaths of more than 9 million people worldwide in 2018, and most of these
deaths were due to metastatic tumor burden. While in most cases, we still do not know why …

To understand the mechanism of acquired resistance to poly (ADP-ribose) polymerase
inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells …

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and
lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid …

Tumors and tumor-derived cell lines contain polyploid giant cells with significantly elevated
genomic content, often with multiple nuclei. The frequency of giant cells can increase …

Polyploidy is associated with increased cell size and is commonly found in a subset of adult
organs and blastomere stage of the human embryo. The polyploidy is formed through …

Life starts with a zygote, which is formed by the fusion of a haploid sperm and egg. The
formation of a blastomere by cleavage division (nuclear division without an increase in cell …

To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and
disease relapse, we examined the mRNA expression profile of PGCCs following treatment …

Tumors arise from the transformation of normal stem cells or mature somatic cells.
Intriguingly, two types of tumors have been observed by pathologists for centuries: well …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …