Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders
B Santoro, MM Shah - Annual review of pharmacology and …, 2020 - annualreviews.org
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
[HTML][HTML] Non-canonical molecular targets for novel analgesics: Intracellular calcium and HCN channels
DC Cook, PA Goldstein - Current Neuropharmacology, 2021 - ncbi.nlm.nih.gov
Pain is a prevalent biopsychosocial condition that poses a significant challenge to
healthcare providers, contributes substantially to a disability, and is a major economic …
healthcare providers, contributes substantially to a disability, and is a major economic …
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
ED Kim, X Wu, S Lee, GR Tibbs, KP Cunningham… - Nature, 2024 - nature.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for
pacemaking activity and neural signalling,. Drugs inhibiting HCN1 are promising candidates …
pacemaking activity and neural signalling,. Drugs inhibiting HCN1 are promising candidates …
The potential antidepressant compound Org 34167 modulates HCN channels via a novel mode of action
CE McKenzie, A Hung, AM Phillips, MS Soh… - Molecular …, 2023 - ASPET
Org 34167 is a small molecule hyperpolarization-activated cyclic nucleotide-gated (HCN)
channel modulator that has been trialed in humans for its potential antidepressant activity …
channel modulator that has been trialed in humans for its potential antidepressant activity …
An anchor-tether 'hindered'HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model
GR Tibbs, R Uprety, JD Warren, NP Beyer… - British Journal of …, 2023 - Elsevier
Background Neuropathic pain impairs quality of life, is widely prevalent, and incurs
significant costs. Current pharmacological therapies have poor/no efficacy and significant …
significant costs. Current pharmacological therapies have poor/no efficacy and significant …