Coordinating Proliferation, Polarity, and Cell Fate in the Drosophila Female Germline
Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …
Production of viable oocytes requires a series of precise and coordinated molecular events …
Nutritional control of insect reproduction
V Smykal, AS Raikhel - Current opinion in insect science, 2015 - Elsevier
Highlights•AA/TOR pathway regulates synthesis and secretion of ILPs as shown for
Drosophila.•ILPs represent a second nutritional checkpoint in regulation of …
Drosophila.•ILPs represent a second nutritional checkpoint in regulation of …
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
RL Wolfson, L Chantranupong, GA Wyant, X Gu… - Nature, 2017 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell
growth that responds to diverse environmental signals and is deregulated in many human …
growth that responds to diverse environmental signals and is deregulated in many human …
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
Mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and metabolism
in response to multiple nutrients, including the essential amino acid leucine. Recent work in …
in response to multiple nutrients, including the essential amino acid leucine. Recent work in …
A network of human functional gene interactions from knockout fitness screens in cancer cells
Genetic interactions mediate the emergence of phenotype from genotype. The systematic
survey of genetic interactions in yeast showed that genes operating in the same biological …
survey of genetic interactions in yeast showed that genes operating in the same biological …
Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster
D Drummond-Barbosa - Genetics, 2019 - academic.oup.com
The long-term survival of any multicellular species depends on the success of its germline in
producing high-quality gametes and maximizing survival of the offspring. Studies in …
producing high-quality gametes and maximizing survival of the offspring. Studies in …
Meiosis initiation: a story of two sexes in all creatures great and small
IF Sou, RM Pryce, WW Tee, UL McClurg - Biochemical Journal, 2021 - portlandpress.com
Meiosis facilitates diversity across individuals and serves as a major driver of evolution.
However, understanding how meiosis begins is complicated by fundamental differences that …
However, understanding how meiosis begins is complicated by fundamental differences that …
Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation
Tissue development and homeostasis depend on the balance between growth and terminal
differentiation, but the mechanisms coordinating these processes remain elusive …
differentiation, but the mechanisms coordinating these processes remain elusive …
The AMPK-PP2A axis in insect fat body is activated by 20-hydroxyecdysone to antagonize insulin/IGF signaling and restrict growth rate
D Yuan, S Zhou, S Liu, K Li, H Zhao… - Proceedings of the …, 2020 - National Acad Sciences
In insects, 20-hydroxyecdysone (20E) limits the growth period by triggering developmental
transitions; 20E also modulates the growth rate by antagonizing insulin/insulin-like growth …
transitions; 20E also modulates the growth rate by antagonizing insulin/insulin-like growth …
SEA you later alli-GATOR–a dynamic regulator of the TORC1 stress response pathway
S Dokudovskaya, MP Rout - Journal of cell science, 2015 - journals.biologists.com
Cells constantly adapt to various environmental changes and stresses. The way in which
nutrient and stress levels in a cell feed back to control metabolism and growth are …
nutrient and stress levels in a cell feed back to control metabolism and growth are …