The Liaison between Metabolism and Oxidative Stress in Human Diseases
Mitochondria have been the prerequisite to eukaryote complexity since their likely
endosymbiotic origin, allowing a remarkable expansion in the number of genes expressed …
endosymbiotic origin, allowing a remarkable expansion in the number of genes expressed …
Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21
J Manji, J Pipella, G Brawerman, PJ Thompson - Epigenomes, 2024 - mdpi.com
Type 1 diabetes (T1D) is a metabolic disease resulting from progressive autoimmune
destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are …
destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are …
Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress
TL MacDonald, B Ryback, J Aparecida da Silva Pereira… - bioRxiv, 2024 - biorxiv.org
Renalase (Rnls), annotated as an oxidase enzyme, is a GWAS gene associated with Type 1
Diabetes (T1D) risk. We previously discovered that Rnls inhibition delays diabetes onset in …
Diabetes (T1D) risk. We previously discovered that Rnls inhibition delays diabetes onset in …