Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
Liver X receptors in lipid signalling and membrane homeostasis
B Wang, P Tontonoz - Nature Reviews Endocrinology, 2018 - nature.com
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …
Lipid metabolism in cancer progression and therapeutic strategies
Y Fu, T Zou, X Shen, PJ Nelson, J Li, C Wu, J Yang… - MedComm, 2021 - Wiley Online Library
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
Lipid metabolic reprogramming in cancer cells
S Beloribi-Djefaflia, S Vasseur, F Guillaumond - Oncogenesis, 2016 - nature.com
Many human diseases, including metabolic, immune and central nervous system disorders,
as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their …
as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their …
Biological properties of propolis extracts: Something new from an ancient product
N Zabaiou, A Fouache, A Trousson, S Baron… - Chemistry and physics …, 2017 - Elsevier
Natural products are an interesting source of new therapeutics, especially for cancer therapy
as 70% of them have botany origin. Propolis, a resinous mixture that honey bees collect and …
as 70% of them have botany origin. Propolis, a resinous mixture that honey bees collect and …
Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts
F Mollinedo, C Gajate - Journal of lipid research, 2020 - ASBMB
Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
Role of cholesterol and lipid rafts in cancer signaling: a promising therapeutic opportunity?
R Vona, E Iessi, P Matarrese - Frontiers in cell and developmental …, 2021 - frontiersin.org
Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …
processes, both physiological and pathological. It is an essential structural constituent of cell …
The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics
PMR Cruz, H Mo, WJ McConathy, N Sabnis… - Frontiers in …, 2013 - frontiersin.org
While the unique metabolic activities of malignant tissues as potential targets for cancer
therapeutics has been the subject of several recent reviews, the role of cholesterol …
therapeutics has been the subject of several recent reviews, the role of cholesterol …
Cholesterol and beyond-The role of the mevalonate pathway in cancer biology
A Göbel, M Rauner, LC Hofbauer… - Biochimica et Biophysica …, 2020 - Elsevier
Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …
Cholesterol metabolic reprogramming in cancer and its pharmacological modulation as therapeutic strategy
I Giacomini, F Gianfanti, MA Desbats, G Orso… - Frontiers in …, 2021 - frontiersin.org
Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …