In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-
independent 1-deoxy-D-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP …

Fosmidomycin plus clindamycin was shown to be efficacious in the treatment of
uncomplicated Plasmodium falciparum malaria in a small cohort of pediatric patients aged 7 …

Capillary electrophoresis is a powerful analytical technique which is increasing in utility in
the pharmaceutical industry. It is used as an alternative or complementary technique to …

A rapid capillary electrophoretic method for the analysis of three alkylphosphonate drugs (ie
fosfomycin disodium (FOS), clodronate disodium (CLO) and alendronate sodium (ALN)) was …

The isoprenoid biosynthesis of Plasmodium falciparum, the causative agent of malignant
tertiana malaria, solely depends on the mevalonate-independent 2-C-methyl-d-erythritol 4 …

A simple, sensitive, selective and reproducible method based on agar diffusion disk assay
was developed for the determination of fosmidomycin and clindamycin in human plasma …

INTRODUCTION: Fosmidomycin is a phosphonic acid derivative originally isolated as a
natural antibiotic from Streptomyces lavendulae. It was originally used as an antibiotic, and …

В отличие от млекопитающих, у некоторых видов патогенных микроорганизмов синтез
изопрсноидов осуществляется по ме-тилэритритолфосфатночу (МЕР) пути. Так как …