Therapeutic implications of tumor microenvironment in lung cancer: focus on immune checkpoint blockade
C Genova, C Dellepiane, P Carrega… - Frontiers in …, 2022 - frontiersin.org
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
Macrophage polarization in physiological and pathological pregnancy
Y Yao, XH Xu, L Jin - Frontiers in immunology, 2019 - frontiersin.org
The immunology of pregnancy is complex and poorly defined. During the complex process
of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in …
of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in …
[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF
S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …
between health and disease. In spite of its central role in physiological homeostasis, it …
Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface
F Yang, Q Zheng, L Jin - Frontiers in immunology, 2019 - frontiersin.org
A successful pregnancy requires a fine-tuned and highly regulated balance between
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …
A micro/nano-biomimetic coating on titanium orchestrates osteo/angio-genesis and osteoimmunomodulation for advanced osseointegration
Osseointegration is a sophisticated bone and implant healing process comprising of initial
hematoma formation, immediate osteoimmunomodulation, angiogenesis, and osteogenesis …
hematoma formation, immediate osteoimmunomodulation, angiogenesis, and osteogenesis …
[HTML][HTML] Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung
In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …
Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke
HY Kim, TJ Kim, L Kang, YJ Kim, MK Kang, J Kim… - Biomaterials, 2020 - Elsevier
Exosomes and extracellular nanovesicles (NV) derived from mesenchymal stem cells (MSC)
may be used for the treatment of ischemic stroke owing to their multifaceted therapeutic …
may be used for the treatment of ischemic stroke owing to their multifaceted therapeutic …
Mechanisms of key innate immune cells in early-and late-onset preeclampsia
I Aneman, D Pienaar, S Suvakov, TP Simic… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …
Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta
MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …
pregnancies worldwide and is characterized by hypertension and damage to multiple …
Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance
S Wang, J Wang, Z Chen, J Luo, W Guo, L Sun… - NPJ Precision …, 2024 - nature.com
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular
heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME) …
heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME) …