Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

There has been an increasing interest in recent years in the stromal cell system functioning
in the support of hematopoiesis. The stromal cell system has been proposed to consist of …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Abstract Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of
maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts …

Oxidative stress contributes to tumourigenesis by altering gene expression. One
accompanying modification, 8-oxoguanine (o8G) can change RNA–RNA interactions via …

Although recent data suggests that osteoblasts play a key role within the hematopoietic stem
cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies …

Despite the need for alternative sources of human hematopoietic stem cells (HSCs), the
functional capacity of hematopoietic cells generated from human embryonic stem cells …

Aberrant activation of the Hedgehog signaling pathway has been implicated in the
maintenance of leukemia stem cell populations in several model systems. PF‐04449913 (PF …

The epithelial component of the thymic microenvironment is indispensable for the
generation of T lymphocytes. Although the heterogeneity of this epithelium is well …