Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …

Tumour-promoting inflammation is considered one of the enabling characteristics of cancer
development. Chronic inflammatory disease increases the risk of some cancers, and strong …

Tumor-associated macrophages (TAMs) constitute the main population of immune cells
present in the ovarian tumor microenvironment. These cells are characterized by high …

Acute inflammation is a response to an alteration induced by a pathogen or a physical or
chemical insult, which functions to eliminate the source of the damage and restore …

Ovarian cancer is the most fatal gynecological cancer in the USA and the fifth most common
cancer-related cause of death in women. Inflammation has been shown to play many roles …

Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues
and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the …

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …