The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

Elevated expression of RNA binding protein HNRNPC has been reported in cancer cells,
while the essentialness and functions of HNRNPC in tumors were not clear. We showed that …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

Initiation of translation in eukaryotic cells can occur by two distinct mechanisms, cap-
dependent scanning and internal ribosome entry. The latter mechanism requires the …

Resveratrol, an edible polyphenolic stilbene, has been reported to possess substantial
antileukemic activities in different leukemia cell lines. We investigated whether resveratrol is …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …

The cell has many ways to regulate the production of proteins. One mechanism is through
the changes to the machinery of translation initiation. These alterations favor the translation …

Internal ribosome entry sites/segments (IRESs) were first discovered over 20 years ago in
picornaviruses, followed by the discovery of two other types of IRES in hepatitis C virus …

The 5′ untranslated region of the proto-oncogene c-myc contains an internal ribosome
entry segment and c-Myc translation can be initiated by cap-independent as well as cap …