The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory
supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both …

The sensory neurons that subserve olfaction, olfactory receptor neurons (ORNs), are
regenerated throughout life, making the neuroepithelium in which they reside [the olfactory …

The mammalian inner ear contains the cochlea and vestibular organs, which are
responsible for hearing and balance, respectively. The epithelia of these sensory organs …

Robust type-I interferon (IFN-α/β) induction in plasmacytoid dendritic cells, through the
activation of Toll-like receptor 9 (TLR9), constitutes a critical aspect of immunity,,,,,. It is …

For mammalian cochlear hair cells, fate determination is normally completed by birth. We
report here that overexpression of Math1, a mouse homolog of the Drosophila gene atonal …

Sensory hair cells and their associated non-sensory supporting cells in the inner ear are
fundamental for hearing and balance. They arise from a common progenitor, but little is …

During embryonic development of the inner ear, the sensory primordium that gives rise to
the organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of …

Strict control of cellular proliferation is required to shape the complex structures of the
developing embryo. The organ of Corti, the auditory neuroepithelium of the inner ear in …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and
supporting cells. Notch signalling is thought to govern this pattern of differentiation through …