Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor
escape from the host immune system. Major gaps in knowledge that impede the …

Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …

The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

As an endogenous neuroprotectant agent, adenosine is extensively distributed and is
particularly abundant in the central nervous system (CNS). Under physiological conditions …

Abstract Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine …

Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …

Diseases of the nervous system have devastating effects and are widely distributed among
the population, being especially prevalent in the elderly. These diseases are often caused …

Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …

Epilepsy is one of the most serious and common chronic neurological conditions,
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …