Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been
attributed to a combination of genetic, environmental and metabolic factors. Chronic …

Abstract Uridine 5′-diphosphoglucose (UDP-G) as a preferential agonist, but also other
UDP-sugars, such as UDP galactose, function as extracellular signaling molecules under …

Inflammation is a defense mechanism that can protect the host against microbe invasion. A
proper inflammatory response can maintain homeostasis, but continuous inflammation can …

About 10 million new cases of dementia develop worldwide each year, of which up to 70%
are attributable to Alzheimer's disease (AD). In addition to the widely known symptoms of …

UDPG/P2Y14R signaling pathway has been considered as a potential therapeutic target for
innate immune system diseases. Based on the scaffold hopping strategy, a series of …

Inflammation and disease are closely related. Inflammation can induce various diseases,
and diseases can promote inflammatory response, and two possibly induces each other in a …

Cancer treatments with targeted therapy have gained immense interest due to their low
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …

Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and
secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is …

The NLRP3 inflammasome, which belongs to the pyrin domain containing 3 family of NOD-
like receptors, has a significant impact on both the innate and adaptive immune responses …

The P2Y14 receptor has been proven to be a potential target for IBD. Herein, we designed
and synthesized a series of 4-amide-thiophene-2-carboxyl derivatives as novel potent …