[HTML][HTML] Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …
Polymeric nanoparticles-siRNA as an emerging nano-polyplexes against ovarian cancer
Ovarian cancer (OC) is considered fifth-deadliest cancer globally responsible for high
mortality in women. As the conventional therapeutic and diagnostic approaches are …
mortality in women. As the conventional therapeutic and diagnostic approaches are …
Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
CM Zimmermann, D Baldassi, K Chan… - Journal of Controlled …, 2022 - Elsevier
While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently
undruggable targets which could potentially be treated with RNA therapeutics. Hence, local …
undruggable targets which could potentially be treated with RNA therapeutics. Hence, local …
Polyethylene glycol and polyethylenimine dual‐functionalized nano‐graphene oxide for photothermally enhanced gene delivery
Graphene oxide (GO) has been extensively explored in nanomedicine for its excellent
physiochemical, electrical, and optical properties. Here, polyethylene glycol (PEG) and …
physiochemical, electrical, and optical properties. Here, polyethylene glycol (PEG) and …
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Small interfering RNAs (siRNAs) are among the most promising therapeutic platforms in
many life-threatening diseases. Owing to the significant advances in siRNA design, many …
many life-threatening diseases. Owing to the significant advances in siRNA design, many …
Action and reaction: the biological response to siRNA and its delivery vehicles
RNA interference (RNAi)-based therapeutics have significant potential for the treatment of
human disease. Safe and effective delivery of RNA to target tissues remains a major barrier …
human disease. Safe and effective delivery of RNA to target tissues remains a major barrier …
Recent developments in nanoparticle‐based siRNA delivery for cancer therapy
JM Lee, TJ Yoon, YS Cho - BioMed research international, 2013 - Wiley Online Library
RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that
enables sequence‐specific gene silencing by promoting degradation of specific mRNAs …
enables sequence‐specific gene silencing by promoting degradation of specific mRNAs …
siRNA therapeutics against respiratory viral infections—What have we learned for potential COVID‐19 therapies?
Acute viral respiratory tract infections (AVRIs) are a major burden on human health and
global economy and amongst the top five causes of death worldwide resulting in an …
global economy and amongst the top five causes of death worldwide resulting in an …
Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes
SARS-CoV-2 has been the cause of a global pandemic since 2019 and remains a medical
urgency. siRNA-based therapies are a promising strategy to fight viral infections. By …
urgency. siRNA-based therapies are a promising strategy to fight viral infections. By …
Controlled pulmonary drug and gene delivery using polymeric nano-carriers
M Beck-Broichsitter, OM Merkel, T Kissel - Journal of controlled release, 2012 - Elsevier
Pulmonary drug and gene delivery to the lung represents a non-invasive avenue for local
and systemic therapies. However, the respiratory tract provides substantial barriers that …
and systemic therapies. However, the respiratory tract provides substantial barriers that …