Microtubule nucleation for spindle assembly: one molecule at a time
The cell orchestrates the dance of chromosome segregation with remarkable speed and
fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) …
fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) …
Augmin is a Ran-regulated spindle assembly factor
Mitotic spindles are composed of microtubules (MTs) that must nucleate at the right place
and time. Ran regulates this process by directly controlling the release of spindle assembly …
and time. Ran regulates this process by directly controlling the release of spindle assembly …
Building on-chip cytoskeletal circuits via branched microtubule networks
Controllable platforms to engineer robust cytoskeletal scaffolds have the potential to create
novel on-chip nanotechnologies. Inspired by axons, we combined the branching …
novel on-chip nanotechnologies. Inspired by axons, we combined the branching …
[HTML][HTML] HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2
In large vertebrate spindles, the majority of microtubules are formed via branching
microtubule nucleation, whereby microtubules nucleate along the side of pre-existing …
microtubule nucleation, whereby microtubules nucleate along the side of pre-existing …
RanGTP regulates the augmin complex
Spindles are composed of microtubules that must nucleate at the right place and time during
mitosis. Spindle microtubule nucleation is regulated by the GTPase Ran, which, through …
mitosis. Spindle microtubule nucleation is regulated by the GTPase Ran, which, through …
Boundary-Sensing Mechanism in Branched Microtubule Networks
The self-organization of cytoskeletal networks in confined geometries requires sensing and
responding to mechanical cues at nanometer to micron scales that allow for dynamic …
responding to mechanical cues at nanometer to micron scales that allow for dynamic …