Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

M Zhang, Q Liu, H Meng, H Duan, X Liu, J Wu… - Signal transduction and …, 2024 - nature.com
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

[HTML][HTML] Adenosine receptor signalling as a driver of pulmonary fibrosis

E Cash, AT Goodwin, AL Tatler - Pharmacology & Therapeutics, 2023 - Elsevier
Pulmonary fibrosis is a debilitating and life-limiting lung condition in which the damage-
response mechanisms of mixed-population cells within the lungs go awry. The tissue …

Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice

X Shi, T Xu, W Cui, X Qi, S Xu - Science of the Total Environment, 2023 - Elsevier
Environmental harmful pollutants microplastics (MPs) and di (2-ethyl) hexyl phthalate
(DEHP) are widely residual in the environment, which may cause lesion to multiple …

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS …

J Fu, S Liu, Q Tan, Z Liu, J Qian, T Li, J Du, B Song… - Molecules, 2022 - mdpi.com
As a cellular protease, transmembrane serine protease 2 (TMPRSS2) plays roles in various
physiological and pathological processes, including cancer and viral entry, such as severe …

[HTML][HTML] Design, synthesis, in silico and antibacterial evaluation of curcumin derivatives loaded nanofiber as potential wound healing agents

AYM Alabdali, R Khalid, M Kzar, MO Ezzat… - Journal of King Saud …, 2022 - Elsevier
Objective Drug resistance can result in mortality and morbidity due to treatment failures.
Therefore, researchers are actively involved in the urgent development of new antibacterial …

Inorganic Phosphate as “Bioenergetic Messenger” Triggers M2‐Type Macrophage Polarization

X Sun, Z Li, X Wang, J He, Y Wu - Advanced Science, 2024 - Wiley Online Library
The effects of calcium phosphate (CaP) materials on macrophage polarization state vary
with their physicochemical properties. The study aims to elucidate the impact of phosphate …

Many faces and functions of GSKIP: a temporospatial regulation view

NS Wu, YF Lin, IC Ma, HJ Ko, YR Hong - Cellular signalling, 2022 - Elsevier
Abstract Glycogen synthase kinase 3 (GSK3)-β (GSK3β) interaction protein (GSKIP) is one
of the smallest A-kinase anchoring proteins that possesses a binding site for GSK3β …

The metabolic role of the CD73/adenosine signaling pathway in HTR-8/SVneo cells: A Double-Edged Sword?

G Song, D Zhang, J Zhu, A Wang, X Zhou, TL Han… - Heliyon, 2024 - cell.com
Abstract The ecto-5′-nucleotidase (CD73)/adenosine signaling pathway has been reported
to regulate tumor epithelial-mesenchymal transition (EMT), migration and proliferation …

Anti-hair loss effect of adenosine is exerted by cAMP mediated wnt/β-catenin pathway stimulation via modulation of Gsk3β activity in cultured human dermal papilla …

J Kim, JY Shin, YH Choi, NG Kang, S Lee - Molecules, 2022 - mdpi.com
In the present study, we investigated the molecular mechanisms of adenosine for its hair
growth promoting effect. Adenosine stimulated the Wnt/β-catenin pathway by modulating the …

[HTML][HTML] The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB …

Y Peng, R Xiong, B Wang, X Chen… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Adenosine receptor-mediated signaling, especially adenosine A 2A receptor (A 2A R)
signaling, has been implicated in wound healing. However, the role of endothelial cells …