Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …

Glioblastoma (GBM) is a high-grade central nervous system malignancy and despite
aggressive treatment strategies, GBM patients have a median survival time of just 1 year …

Acridine derivatives constitute a class of compounds that are being intensively studied as
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …

The p53 and nuclear factor-κB (NF-κB) pathways play crucial roles in human cancer, in
which inactivation of p53 and hyperactivation of NF-κB is a common occurrence. Activation …

This is an in-depth review of the history of quinacrine as well as its pharmacokinetic
properties and established record of safety as an FDA-approved drug. The potential uses of …

Introduction: Acridine derivatives have been extensively explored as potential therapeutic
agents for the treatment of a number of diseases, such as cancer, Alzheimer's, and bacterial …

Abstract p53 acts as a central mediator of the cellular response to stressful stimuli. The
growth-suppressive function of p53 is lost with mutation and this occurs commonly in human …

Mutations in the tumor suppressor p53 are detectable in over 50% of all human
malignancies. Mutant p53 protein is incapable of transactivating its downstream target …

Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor
drug transportation across the blood–brain barrier and the existence of glioma stem cells …