A global view of hepatocellular carcinoma: trends, risk, prevention and management

JD Yang, P Hainaut, GJ Gores, A Amadou… - Nature reviews …, 2019 - nature.com
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death
worldwide. Risk factors for HCC include chronic hepatitis B and hepatitis C, alcohol …

[HTML][HTML] Data resource profile: the national health insurance research database (NHIRD)

LY Lin, C Warren-Gash, L Smeeth… - Epidemiology and …, 2018 - ncbi.nlm.nih.gov
Electronic health records (EHRs) can provide researchers with extraordinary opportunities
for population-based research. The National Health Insurance system of Taiwan was …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Aristolochic acid-associated cancers: a public health risk in need of global action

S Das, S Thakur, M Korenjak, VS Sidorenko… - Nature Reviews …, 2022 - nature.com
Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …

[HTML][HTML] Systematic overview of aristolochic acids: nephrotoxicity, carcinogenicity, and underlying mechanisms

J Han, Z Xian, Y Zhang, J Liu, A Liang - Frontiers in Pharmacology, 2019 - frontiersin.org
Aristolochic acids (AAs) are a group of toxins commonly present in the plants of genus
Aristolochia and Asarum, which are spread all over the world. Since the 1990s, AA-induced …

[PDF][PDF] 中国人群肝癌筛查指南(2022, 北京)

赫捷, 陈万青, 沈洪兵, 李霓, 曲春枫, 石菊芳, 孙凤… - 中华肿瘤杂志, 2022 - dzrmyy.com
中国人群的肝癌存在生存率低, 死亡率高的情况, 如何有效降低肝癌相关负担仍是中国公共卫生
和慢性病防控领域亟待解决的重大问题, 而肝癌人群筛查策略优化是值得持续探索的重要抓手和 …

Herbal products containing aristolochic acids: A call to revisit the context of safety

LP Ang, PW Ng, YL Lean, V Kotra, N Kifli… - Journal of Herbal …, 2021 - Elsevier
Herbal products are used globally for their perceived health benefits, and as a complement
to alternative therapy to Western medicines. Herbal products can be beneficial, although …

Co-exposure to aristolochic acids I and II increases DNA adduct formation responsible for aristolochic acid I-mediated carcinogenicity in rats

F Bárta, A Dedíková, M Bebová, Š Dušková… - International journal of …, 2021 - mdpi.com
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as
major components, causes aristolochic acid nephropathy (AAN) and Balkan endemic …

Integrated genomic analyses of hepatocellular carcinoma

YS Chang, SJ Tu, HD Chen, MH Hsu, YC Chen… - Hepatology …, 2023 - Springer
Background Genomic alterations play important roles in the development of cancer. We
explored the impact of protein-coding genes and transcriptomic changes on clinical and …

[PDF][PDF] Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics

P Luo, J Chen, Q Zhang, F Xia, C Wang… - Precision Clinical …, 2022 - academic.oup.com
Abstract Background Aristolochic acids (AAs), a class of carcinogenic and mutagenic natural
products from Aristolochia and Asarum plants, are well-known to be responsible for inducing …