SARS-CoV-2 detection, viral load and infectivity over the course of an infection

KA Walsh, K Jordan, B Clyne, D Rohde, L Drummond… - Journal of Infection, 2020 - Elsevier
Objectives To summarise the evidence on the detection pattern and viral load of SARS-CoV-
2 over the course of an infection (including any asymptomatic or pre-symptomatic phase) …

[HTML][HTML] The trinity of COVID-19: immunity, inflammation and intervention

MZ Tay, CM Poh, L Rénia, PA MacAry… - Nature Reviews …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …

[HTML][HTML] Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness

R Ke, PP Martinez, RL Smith, LL Gibson, A Mirza… - Nature …, 2022 - nature.com
The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly
understood. We captured the dynamics of infectious virus and viral RNA shedding during …

[HTML][HTML] Real-time RT-PCR in COVID-19 detection: issues affecting the results

A Tahamtan, A Ardebili - Expert review of molecular diagnostics, 2020 - Taylor & Francis
Due to the rapid spread and increasing number of coronavirus disease 19 (COVID-19)
cases caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 …

Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis

KS Cheung, IFN Hung, PPY Chan, KC Lung, E Tso… - Gastroenterology, 2020 - Elsevier
Background & Aims Infection with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) causes coronavirus disease 2019 (COVID-19), which has been characterized by …

[HTML][HTML] COVID-19, SARS and MERS: are they closely related?

N Petrosillo, G Viceconte, O Ergonul, G Ippolito… - Clinical microbiology …, 2020 - Elsevier
Background The 2019 novel coronavirus (SARS-CoV-2) is a new human coronavirus which
is spreading with epidemic features in China and other Asian countries; cases have also …

COVID-19: towards controlling of a pandemic

J Bedford, D Enria, J Giesecke, DL Heymann… - The lancet, 2020 - thelancet.com
WHO Research and Development Blueprint Scientific Advisory Group that met on March 2,
2020, in Geneva, Switzerland, to prioritise the recommendations of an earlier meeting on …

Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening

DB Larremore, B Wilder, E Lester, S Shehata… - Science …, 2021 - science.org
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can
spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the …

[HTML][HTML] Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

VJ Munster, F Feldmann, BN Williamson… - Nature, 2020 - nature.com
An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel
coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started …

[HTML][HTML] Molecular diagnostic technologies for COVID-19: Limitations and challenges

A Afzal - Journal of advanced research, 2020 - Elsevier
Background To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the
world needs diagnostic systems capable of rapid detection and quantification of the novel …